The Critical Need for Accurately Defining Digital Ulcers in Scleroderma
نویسندگان
چکیده
منابع مشابه
Digital ulcers and outcomes assessment in scleroderma.
Ischaemic ulcerations of the fingertips are common in SSc and a source of pain and disability. Healing has been demonstrated with intravenous iloprost and two studies with bosentan have demonstrated reduction in the occurrence of new digital ulcers (DUs) over 4-6 months of treatment. Both bosentan studies showed no benefit in healing DU and because of this, net DU burden is no different between...
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Raynaud, digital ulcers and calcinosis are frequent manifestations of patients with systemic sclerosis. Digital ulcers are seen in more than half of the patients with scleroderma. Hospitalizations, ischemic complications and impairment of hand function are frequently observed in patients with digital ulcers, especially if treatment is delayed. Rapid and intensive treatment escalation in patient...
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ER: extended release HDACi: Histone deacetylase inhibitor TSA: trichostatin A TGF-b: Transforming growth factor beta INTRODUCTION Scleroderma is an autoimmune connective tissue disease that involves the skin and internal organs for which there are few reliably effective treatments. The cutaneous manifestations of scleroderma include fibrosis and sclerodactyly, calcinosis cutis, digital ulcers, ...
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ژورنال
عنوان ژورنال: Journal of Scleroderma and Related Disorders
سال: 2017
ISSN: 2397-1983,2397-1991
DOI: 10.5301/jsrd.5000238